PT  - JOURNAL ARTICLE
AU  - Steinberg, Robert B.
AU  - Dunn, Steven M.
AU  - Powell, George
AU  - Hu, Xiaohan
TI  - Epidural Sufentanil for Analgesia for Labor and Delivery
AID  - 10.1136/rapm-00115550-198914050-00005
DP  - 1989 Sep 01
TA  - Regional Anesthesia: The Journal of Neural Blockade in Obstetrics, Surgery, & Pain Control
PG  - 225--228
VI  - 14
IP  - 5
4099  - http://rapm.bmj.com/content/14/5/225.short
4100  - http://rapm.bmj.com/content/14/5/225.full
SO  - Reg Anesth Pain Med1989 Sep 01; 14
AB  - Six groups of ten women each in active labor at term had epidural catheters placed in the usual manner and received a 3 mL test dose of 2% lidocaine with epinephrine. Groups 1-6 received, respectively, 5, 10, 20, 30, 40 and 50 μg of sufentanil diluted to 10 mL with normal saline. Significantly effective analgesia was provided at all sufentanil doses studied, with pain scores decreasing from 8.1 ± 0.2 at baseline to 2.9 ± 0.3 at 10 minutes and 1.1 ± 0.2 at 30 minutes (mean ± SEM, average for all groups). The duration of analgesia showed a significant ( p < 0.05) relation to sufentanil dose, increasing from 79.1 ± 11.3 minutes (5-μg group) to 137.8 ± 17.2 minutes (50-μg group). There were no serious maternal side effects, although ten patients developed pruritis, four became dizzy, two experienced mild sedation, and one had transient hypotension. No neonatal side effects occurred. Maternal serum sufentanil levels remained below the sensitivity of the assay, or 0.1 ng/ml.