PT  - JOURNAL ARTICLE
AU  - Mukkada, Thresiamma A.
AU  - Bridenbaugh, Phillip O.
AU  - Singh, Pritam
AU  - Edström, Håkan H.
TI  - Effects of Dose, Volume, and Concentration of Glucose-free Bupivacaine in Spinal Anesthesia
AID  - 10.1136/rapm-00115550-198611020-00012
DP  - 1986 Apr 01
TA  - Regional Anesthesia: The Journal of Neural Blockade in Obstetrics, Surgery, & Pain Control
PG  - 98--101
VI  - 11
IP  - 2
4099  - http://rapm.bmj.com/content/11/2/98.short
4100  - http://rapm.bmj.com/content/11/2/98.full
SO  - Reg Anesth Pain Med1986 Apr 01; 11
AB  - The effects of total dose, volume, and concentration of glucose-free bupivacaine in spinal anesthesia were investigated in a double-blind study in 60 men undergoing transurethral surgery. The patients were randomly divided into six groups, receiving 10, 15, or 20 mg, respectively, in either a 0.5% or a 0.75% solution. The longest duration of analgesia (measured at L5 level) and complete motor blockade was obtained with 15 to 20 mg of either solution of bupivacaine, at 4 and 3 hours, respectively. Regardless of concentration of the bupivacaine solution, 10 mg was statistically significantly shorter-acting than 15 and 20 mg, between which no statistically significant differences were found. Systolic and diastolic blood pressures and heart rate decreased 5 to 10% in all groups, taking into account that nine patients were treated for hypotension and/or bradycardia. Post-lumbar puncture headache was not observed in any patient. The quality of spinal anesthesia with glucose-free bupivacaine seems to be related more to the total dose than to the volume or concentration of the solution.